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Atrophy of the Corpus Callosum, Cortical Hypometabolism, and Cognitive Impairment in Corticobasal Degeneration Arch Neurol 55:609-614, Yamauchi,H.,et al, 1998 See this aricle in Pubmed Article Abstract Compared with 36 age-matched right-handed control subjects,the patient shad significantly decreased callosal area-skull area ratio.The reduction in this ratio was greatest in the middle half of the corpus callosum.The atrophy of the corpus callosum was accompanied by a decreased mean cortical glucose metabolic rate with hemispheric asymmetry and a decrease in the sum of the scaled subtest scores of the Wechsler Adult Intelligence Scale-Revised.Atrophy of the corpus callosum with middle predominance is present in corticobasal degeneration,and this atrophy is associated with cognitive impairment and cerebral cortical hypometabolism with hemispheric asymmetry.Atrophy of the corpus callosum might reflect the severity of the disconnection between cortical regions and this may be an important factor in the development of cerebral cortical dysfunction in corticobasal degeneration.

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(click to filter results - removes previous filter) cognition corpus callosum corpus callosum,atrophy of cortical-basal ganglionic degeneration intellectual deficit MRI MRI,abnormal psychological testing

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